ARPP21 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA5101481

Catalog No. PIPA5101481

Description

Antibody detects endogenous levels of total ARPP21.

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 41-81 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1). At least two transcript variants encoding the same protein have been found for this gene.

Specifications

• Antigen: ARPP21
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ARPP21
• Gene Alias: 0710001E13Rik; AI853636; ARPP21; Arpp-21; cAMP regulated phosphoprotein 21; cAMP regulated phosphoprotein 21kDa; cAMP-regulated phosphoprotein (21 kDa); cAMP-regulated phosphoprotein 21; cyclic AMP-regulated phosphoprotein 21; cyclic AMP-regulated phosphoprotein, 21; cyclic AMP-regulated phosphoprotein, 21 kD; D9Bwg1012e; Ppp1r1c; Ppp1r1cl; protein phosphatase 1, regulatory (inhibitory subunit 1C); protein phosphatase 1, regulatory (inhibitory) subunit 1C; protein phosphatase 1, regulatory subunit 1C; R3H domain containing 3; R3HDM3; RCS; Regulator of calmodulin signaling; RGD1307208; RGD1307215; TARPP; thymocyte ARPP; thymocyte cAMP-regulated phosphoprotein
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10777, 363153, 74100
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q9DCB4, Q9UBL0
• Gene Symbols: ARPP21
• Immunogen: A synthesized peptide derived from human ARPP21(Accession Q9UBL0), corresponding to amino acid residues S218-R268.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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