Invitrogen™ ARRDC1 Polyclonal Antibody

Catalog No.	Quantity
PA550913	100 μL

Catalog No. PA550913 Supplier Invitrogen™ Supplier No. PA550913

Description

Rabbit Polyclonal Antibody

ARRDC1 Polyclonal Antibody detects endogenous levels of ARRDC1 protein.

Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (PubMed:23886940, PubMed:27462458). Through an ubiquitination-dependent mechanism plays for instance a role in the incorporation of SLC11A2 into extracellular vesicles (PubMed:27462458). More generally, plays a role in the extracellular transport of proteins between cells through the release in the extracellular space of microvesicles (PubMed:22315426). By participating in the ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, negatively regulates the NOTCH signaling pathway (PubMed:23886940). [UniProt].

Specifications

• Antigen: ARRDC1
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.5% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene: ARRDC1
• Gene Accession No.: Q8N5I2, Q99KN1
• Gene Alias: AI957342; alpha-arrestin 1; Arrdc1; arrestin domain containing 1; arrestin domain-containing protein 1; BC004091
• Gene Symbols: ARRDC1
• Host Species: Rabbit
• Immunogen: Synthesized peptide derived from the Internal region of human Arrdc1 (aa 167-216).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 215705, 366001, 92714
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG