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Invitrogen™ ARRDC1 Polyclonal Antibody
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Catalog No. PIPA560681
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100 μL
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PIPA560681 100 μL
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Catalog No. PIPA560681 Supplier Invitrogen™ Supplier No. PA560681
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: IHTPRFSKDH KCSLVFYILS PLNLNSIPDI EQPNVASATK KFSYKLVKTG SVVLTASTDL RGYVVGQALQ LHADVE Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 92%.

Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (PubMed:23886940, PubMed:27462458). Through an ubiquitination-dependent mechanism plays for instance a role in the incorporation of SLC11A2 into extracellular vesicles (PubMed:27462458). More generally, plays a role in the extracellular transport of proteins between cells through the release in the extracellular space of microvesicles (PubMed:22315426). By participating in the ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, negatively regulates the NOTCH signaling pathway (PubMed:23886940). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen ARRDC1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene ARRDC1
Gene Accession No. Q8N5I2
Gene Alias AI957342; alpha-arrestin 1; Arrdc1; arrestin domain containing 1; arrestin domain-containing protein 1; BC004091
Gene Symbols ARRDC1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human ARRDC1. Recombinant protein control fragment (Product #RP-93114).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 92714
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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