Invitrogen™ ARRDC1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA599589

Catalog No. PIPA599589

Description

Antibody detects endogenous levels of total Arrdc1.

Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (PubMed:23886940, PubMed:27462458). Through an ubiquitination-dependent mechanism plays for instance a role in the incorporation of SLC11A2 into extracellular vesicles (PubMed:27462458). More generally, plays a role in the extracellular transport of proteins between cells through the release in the extracellular space of microvesicles (PubMed:22315426). By participating in the ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, negatively regulates the NOTCH signaling pathway (PubMed:23886940). [UniProt].

Specifications

• Antigen: ARRDC1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ARRDC1
• Gene Alias: AI957342; alpha-arrestin 1; Arrdc1; arrestin domain containing 1; arrestin domain-containing protein 1; BC004091
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 366001, 92714
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q8N5I2
• Gene Symbols: ARRDC1
• Immunogen: A synthesized peptide derived from human ARRDC1(Accession Q8N5I2), corresponding to amino acid residues S389-S433.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG