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ARRY 520 trifluoroacetate, Tocris Bioscience™

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Quantity:
10mg
This item is not returnable. View return policy
885060-09-3
C20H22F2N4O2S
420.479
LLXISKGBWFTGEI-FQEVSTJZSA-N
arry-520,filanesib,unii-8a49oso368,arry 520 trifluoroacetate,2s-2-3-aminopropyl-5-2,5-difluorophenyl-n-methoxy-n-methyl-2-phenyl-1,3,4-thiadiazole-3 2h-carboxamide,arry 520,filanesib inn,filanesib usan:inn,arry520,arry-520; filanesib
44224257
(2S)-2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3-carboxamide
CN(C(=O)N1C(SC(=N1)C2=C(C=CC(=C2)F)F)(CCCN)C3=CC=CC=C3)OC
This item is not returnable. View return policy
885060-09-3
C20H22F2N4O2S
420.479
LLXISKGBWFTGEI-FQEVSTJZSA-N
arry-520,filanesib,unii-8a49oso368,arry 520 trifluoroacetate,2s-2-3-aminopropyl-5-2,5-difluorophenyl-n-methoxy-n-methyl-2-phenyl-1,3,4-thiadiazole-3 2h-carboxamide,arry 520,filanesib inn,filanesib usan:inn,arry520,arry-520; filanesib
44224257
(2S)-2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3-carboxamide
CN(C(=O)N1C(SC(=N1)C2=C(C=CC(=C2)F)F)(CCCN)C3=CC=CC=C3)OC

Description

Potent and selective kinesin spindle protein (KSP) inhibitor; induces Mcl-1 degradation

Potent kinesin spindle protein (KSP) inhibitor (IC50 = 6 nM); selective for KSP over >250 other receptors and kinases at a concentration of 10 μM. Displays robust antitumor activity in bortezomib-resistant xenografts either alone or in combination with bortezomib. Induces degradation of Mcl-1; exhibits comparable cytotoxic activity to taxol (Cat. No. 1097) in epithelial ovarian cancer cells. Active in vivo.
Quantity 10mg
Formula Weight 420.48
Percent Purity >98%
Chemical Name or Material ARRY 520 trifluoroacetate

Safety and Handling

Recommended Storage : Store at -20°C