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Tocris Bioscience™ ARRY 520 trifluoroacetate
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Catalog No. 467610
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10 mg
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Catalog No. Quantity
46-761-0 10 mg
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Description

Potent and selective kinesin spindle protein (KSP) inhibitor; induces Mcl-1 degradation

Potent kinesin spindle protein (KSP) inhibitor (IC50 = 6 nM); selective for KSP over >250 other receptors and kinases at a concentration of 10 μM. Displays robust antitumor activity in bortezomib-resistant xenografts either alone or in combination with bortezomib. Induces degradation of Mcl-1; exhibits comparable cytotoxic activity to taxol (Cat. No. 1097) in epithelial ovarian cancer cells. Active in vivo.

Chemical Identifiers

CAS 885060-09-3
Molecular Formula C20H22F2N4O2S

Specifications

Quantity 10 mg
Formula Weight 420.48
Purity >98%
Molecular Weight (g/mol) 420.479
Chemical Name or Material ARRY 520 trifluoroacetate

Safety and Handling

Recommended Storage Store at -20°C
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