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Invitrogen™ ARS2 Polyclonal Antibody
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Catalog No. PIPA531593
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100 μL
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PIPA531593 100 μL
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Catalog No. PIPA531593 Supplier Invitrogen™ Supplier No. PA531593
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: 293T, A431, Jurkat, Raji, HeLa, HepG2. Predicted reactivity: Mouse (97%), Zebrafish (80%), Bovine (97%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription. [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen ARS2
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.76 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene SRRT
Gene Accession No. Q9BXP5
Gene Alias 2810019G02Rik; Ars2; arsenate resistance protein 2; arsenate resistance protein ARS2; arsenite resistance protein; arsenite resistance protein 2; arsenite-resistance protein 2; Asr2; ASR2A; ASR2B; ASR2C; ASR2D; ch211-283g2.4; CHUNP6881; LOC686980; serrate; Serrate RNA effector molecule homolog; serrate RNA effector molecule homolog (Arabidopsis); serrate, RNA effector molecule; similar to arsenate resistance protein 2; srrt; zgc:92060
Gene Symbols SRRT
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the N-terminus region of human ARS2. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 51593
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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