Invitrogen™ ARS2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA560148

Catalog No. PIPA560148

Description

Immunogen sequence: TCSLFMRNIA PNISRAEIIS LCKRYPGFMR VALSEPQPER RFFRRGWVTF DRSVNIKEIC WNLQNIRLRE CELSPGVNRD LTRRVRNING ITQHKQI Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 43%.

Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription. [UniProt].

Specifications

• Antigen: ARS2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SRRT
• Gene Alias: 2810019G02Rik; Ars2; arsenate resistance protein 2; arsenate resistance protein ARS2; arsenite resistance protein; arsenite resistance protein 2; arsenite-resistance protein 2; Asr2; ASR2A; ASR2B; ASR2C; ASR2D; ch211-283g2.4; CHUNP6881; LOC686980; serrate; Serrate RNA effector molecule homolog; serrate RNA effector molecule homolog (Arabidopsis); serrate, RNA effector molecule; similar to arsenate resistance protein 2; srrt; zgc:92060
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 51593
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9BXP5
• Gene Symbols: SRRT
• Immunogen: Recombinant protein corresponding to Human ARS2. Recombinant protein control fragment (Product #RP-92626).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov