Invitrogen™ ARTS Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA520001

Catalog No. PIPA520001

Description

In Western blot applications, this antibody detects a band at ~32kDa. A suggested positive control is human lung tissue lysate. PA5-20001 can be used with blocking peptide PEP-0123.

Apoptosis is related to many diseases and development. Mitochondrial proteins, such as cytochrome c, Apaf-1, and AIF play important role in apoptosis. A novel mitochondrial septin-like protein was identified recently and designated ARTS for apoptosis related protein in TGF-beta signaling pathway. ARTS that is encoded by the human septin H5/PNUTL2/CDCrel2b gene is located to mitochondria and translocates to the nucleus when apoptosis occurs. ARTS is expressed in many tissues. It enhances cell death induced by TGF-beta and, to a lesser extent, by other apoptotic agents, such as TNF-a and Fas ligand.

Specifications

• Antigen: ARTS
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SEPTIN4
• Gene Alias: 4-Sep; apoptosis-related protein in the TGF-beta signaling pathway; ARTS; Bh5; BRADEION; Bradeion beta; brain protein H5; C17orf47; CE5B3; CE5B3 beta; cell division control-related protein 2; cell division control-related protein 2b; cerebral protein 7; EG3-1RVC; EG3RVC; expression gene 3 in rat visual cortex; expression gene 3-1 in rat visual cortex; H5; hCDCREL-2; hucep-7; MART; M-Septin; OTTMUSG00000001265; peanut-like 2; peanut-like 2 homolog; peanut-like protein 2; PNUTL2; SEP4; Sept4; septin 4; septin H5; Septin4; septin-4; septin-M; Uncharacterized protein C17orf47
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5414
• Content And Storage: Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: O43236
• Gene Symbols: SEPTIN4
• Immunogen: A synthetic peptide corresponding to amino acids near the amino terminus of human ARTS.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG