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  5. Tocris Bioscience™ AS 1517499

Tocris Bioscience™ AS 1517499
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Catalog No. 763610
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76-361-0 10 mg
76-365-0 50 mg
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Catalog No. 76-361-0 Supplier Tocris Bioscience™ Supplier No. 7636/10
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Description

STAT6 inhibitor

AS 1517499 is a potent STAT6 inhibitor (IC50 = 21 nM). In vitro, it inhibits IL-4-induced Th2 differentiation of mouse spleen T cells (IC50 = 2.3 nM), without influencing Th1 differentiation induced by IL-12. In a mouse model of allergic bronchial asthma, treatment with AS 1517499 reduces mouse airway IL-3 production and partly inhibits the RhoA upregulation in bronchial smooth muscles.

Specifications

Chemical Name or Material 2-[[2-(3-Chloro-4-hydroxyphenyl)ethyl]amino]-4-[(phenylmethyl)amino]-5-pyrimidinecarboxamide
CAS 919486-40-1
Quantity 10 mg
Target STAT6
Molecular Formula C20H20ClN5O2
Purity 0.98
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