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Tocris Bioscience™ AS 2444697



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Quantity:
10 mg
50 mg
Description
AS 2444697 is a potent and selective interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor (IC50 = 21 nM). Displays 30-fold selectivity for IRAK4 over IRAK1. Inhibits LPS-induced TNF-α and IL-6 production in PBMCs in vitro. Renoprotective and anti-inflammatory in a rodent model of chronic kidney disease.
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Specifications
Specifications
Chemical Name or Material | N-[3-Aminocarbonyl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]-2-(2-methyl-4-pyridinyl)-4-oxazolecarboxamide hydrochloride |
CAS | 1287665-60-4 |
Quantity | 50 mg |
Target | Other Kinase Inhibitors |
Molecular Formula | C19H20N6O4.HCl |
Formula Weight | 432.86 |
Purity | >98% |
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