Tocris Bioscience™ AS 2444697

Description

Potent and selective IRAK4 inhibitor

AS 2444697 is a potent and selective interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor (IC50 = 21 nM). Displays 30-fold selectivity for IRAK4 over IRAK1. Inhibits LPS-induced TNF-α and IL-6 production in PBMCs in vitro. Renoprotective and anti-inflammatory in a rodent model of chronic kidney disease.

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Specifications

• Chemical Name or Material: N-[3-Aminocarbonyl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]-2-(2-methyl-4-pyridinyl)-4-oxazolecarboxamide hydrochloride
• CAS: 1287665-60-4
• Quantity: 50 mg
• Target: Other Kinase Inhibitors
• Molecular Formula: C₁₉H₂₀N₆O₄.HCl
• Formula Weight: 432.86
• Purity: >98%