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Tocris Bioscience™ AS 2444697
GSA_VAGREENER_CHOICE

Catalog No. 543050
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Potent and selective IRAK4 inhibitor

AS 2444697 is a potent and selective interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor (IC50 = 21 nM). Displays 30-fold selectivity for IRAK4 over IRAK1. Inhibits LPS-induced TNF-α and IL-6 production in PBMCs in vitro. Renoprotective and anti-inflammatory in a rodent model of chronic kidney disease.

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Specifications

Chemical Name or Material N-[3-Aminocarbonyl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]-2-(2-methyl-4-pyridinyl)-4-oxazolecarboxamide hydrochloride
CAS 1287665-60-4
Quantity 50 mg
Target Other Kinase Inhibitors
Molecular Formula C19H20N6O4.HCl
Formula Weight 432.86
Purity >98%
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