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Tocris Bioscience™ AS2717638
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Catalog No. 773010
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Quantity:
10 mg
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Description

Selective, brain penetrant LPA5 antagonist

AS2717638 is a potent LPA5 receptor antagonist (IC50 = 38 nM in BV-2 microglia cells). It is selective for LPA5 over LPA1, LPA2, and LPA3. It inhibits LPA-mediated pro-inflammatory transcription factor phosphorylation. In vivo, AS2717638 inhibits LPA5 agonist-induced allodynia in mice. It also exhibits analgesic effects against both neuropathic and inflammatory pain in rodent models. Orally bioavailable and brain penetrant.

Specifications

Chemical Name or Material 6,7-Dimethoxy-2-(5-methyl-1,2-benzisoxazol-3-yl)-4-(1-piperidinylcarbonyl)-1(2 H)-isoquinolinone
CAS 2148339-28-8
Quantity 10 mg
Target LPAR5/LPA5/GPR92
Molecular Formula C25H25N3O5
Purity 0.98
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