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Invitrogen™ ASAH1 Polyclonal Antibody
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Catalog No. PIPA5100089
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PIPA5100089 100 μL
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Catalog No. PIPA5100089 Supplier Invitrogen™ Supplier No. PA5100089
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total ASAH1.

ASAH1 encodes a member of the acid ceramidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. The processing of this preproprotein generates alpha and beta subunits that heterodimerize to form the mature lysosomal enzyme, which catalyzes the degradation of ceramide into sphingosine and free fatty acid. This enzyme is overexpressed in multiple human cancers and may play a role in cancer progression. Mutations in this gene have been linked to the lysosomal storage disorder, Farber lipogranulomatosis, and a neuromuscular disorder, spinal muscular atrophy with progressive myoclonic epilepsy. The related pathways include Innate Immune System and Sphingolipid metabolism. Diseases associated with ASAH1 include Farber Lipogranulomatosis and Spinal Muscular Atrophy With Progressive Myoclonic Epilepsy.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ASAH1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene ASAH1
Gene Accession No. Q13510, Q6P7S1, Q9WV54
Gene Alias 2310081N20Rik; AC; ACDase; acid CDase; acid ceramidase; Acid ceramidase subunit alpha; Acid ceramidase subunit beta; Acylsphingosine deacylase; ASAH; Asah1; HSD33; HSD-33; N-acylethanolamine hydrolase ASAH1; N-acylsphingosine amidohydrolase; N-acylsphingosine amidohydrolase (acid ceramidase) 1; N-acylsphingosine amidohydrolase 1; PHP; PHP32; putative 32 kDa heart protein; SMAPME
Gene Symbols ASAH1
Host Species Rabbit
Immunogen A synthesized peptide derived from human ASAH1(Accession Q13510), corresponding to amino acid residues L12-W62.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11886, 427, 84431
Target Species Human, Mouse, Rat, Monkey
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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