Invitrogen™ ASAHL Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA547629

Catalog No. PIPA547629

Description

In Western blots, approximately 25% cross-reactivity with recombinant mouse ASAHL is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

N-acylsphingosine amidohydrolase-like 1 (ASAHL), commonly referred to as acid ceramidase-like protein, is a gene located on human chromosome 22q13.31. ASAHL encodes a protein that functions as a ceramidase, responsible for hydrolyzing ceramide into sphingosine and fatty acid, which are pivotal for cell signaling pathways that regulate cell growth, differentiation, and apoptosis. Though similar to acid ceramidase, ASAHL's specific biological role and tissue distribution remain active research areas, suggesting potential involvement in lipid metabolism and cellular homeostasis. Dysregulation of ceramidase activity, including ASAHL, is linked to various diseases, such as cancer, neurodegenerative disorders, and metabolic syndromes, due to the crucial role of sphingolipid signaling in these conditions. The gene's activity may influence ceramide levels within cells, impacting susceptibility to apoptosis and other cell fate decisions, highlighting its importance in pathophysiological contexts.

Specifications

• Antigen: ASAHL
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Naaa
• Gene Alias: 2210023K21Rik; 3830414F09Rik; acid ceramidase-like protein; Asahl; ASAH-like protein; LOW QUALITY PROTEIN: N-acylethanolamine-hydrolyzing acid amidase; Naaa; N-acylethanolamine acid amidase; N-acylethanolamine-hydrolyzing acid amidase; N-acylethanolamine-hydrolyzing acid amidase subunit alpha; N-acylethanolamine-hydrolyzing acid amidase subunit beta; N-acylsphingosine amidohydrolase-like; PLT
• Host Species: Goat
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 27163
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunoprecipitation, Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: Q02083
• Gene Symbols: Naaa
• Immunogen: CHO-derived recombinant human ASAHL/N-acylethanolamine-hydrolyzing Acid A isoform 1 Ser29-Lys359 (Val151Ile).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG