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ASAP1 Polyclonal Antibody, Invitrogen™

Catalog No. PIPA125511
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PIPA125511 50 μL
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Catalog No. PIPA125511 Supplier Thermo Scientific Supplier No. PA125511

Description

Rabbit Polyclonal Antibody

Recommended positive controls: rat brain, mouse brain, NIH3T3. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

ASAP1, also known as Development and differentiation enhancing factor 1, is a protein with two ANK repeats, an Arf-GAP domain, a PH domain and a SH3 domain. ASAP1 is a homodimer known to interact with SRC and CRK and its activity is stimulated by phosphatidylinositol 4,5-biphosphate (PIP2). It possesses phosphatidylinositol 4,5-biphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. It may coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2 and may also function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. It is widely expressed in most of the tissues. ASAP1 is a protooncogene involved in invasive breast cancer and in other types of invasive and malignant tumors, such as uveal melanomas.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ASAP1
Applications Immunocytochemistry, Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation 0.01M PBS with 15mM sodium azide; pH 7.4
Gene ASAP1
Gene Accession No. Q1AAU6, Q9QWY8, Q9ULH1
Gene Alias 130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein; 130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein; ADP-ribosylation factor-directed GTPase-activating protein 1; AMAP1; ARF GTPase-activating protein 1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1; ArfGAP with SH3 domain, ankyrin repeat and PH domain 1; ArfGAP with SH3 domain, ankyrin repeat and PH domain1; Asap1; AV239055; centaurin, beta 4; CENTB4; Ddef1; DEF-1; development and differentiation enhancing factor 1; development and differentiation-enhancing factor 1; differentiation enhancing factor 1; differentiation-enhancing factor 1; Kiaa1249; mKIAA1249; PAG2; PAP; PIP2-dependent ARF1 GAP; s19; Shag1; src SH3 binding protein; ZG14P
Gene Symbols ASAP1
Host Species Rabbit
Immunogen Synthetic peptide, conjugated to KLH, corresponding to residues 962-978 of mouse Centaurin beta 4 (ASAP1). The peptide sequence is identical in mouse
Purification Method IgG fraction
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 13196, 314961, 50807
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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