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Invitrogen™ ASAP2 Polyclonal Antibody
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Catalog No. FEPA5144952
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100 μL
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FEPA5144952 100 μL
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Catalog No. FEPA5144952 Supplier Invitrogen™ Supplier No. PA5144952
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: WRLLHEDLDE SDDDMDEKLQ PSPNRREDRP ISFYQLGSNQ LQSNAVSLAR DAANLAKDKQ RAFMPSILQN ETY Antigen sequence identity: Mouse 89%; Rat 88%.

ASAP2 is a multidomain protein belonging to the beta family with two ANK repeats, an Arf-GAP domain, a PH domain and a SH3 domain. This protein localizes in the Golgi apparatus and also at the plasma membrane where it colocalizes with protein tyrosine kinase 2-beta (PYK2) and forms a stable complex with PYK2 in vivo. ASAP2 is tyrosine phosphorylated by activated PYK2. It functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. ASAP2 activates the small GTPases ARF1, ARF5 and ARF6 and regulates the formation of post-Golgi vesicles and modulates constitutive secretion. It modulates phagocytosis mediated by Fc gamma receptor and ARF6. Usually detected in heart, brain, placenta, kidney, monocytes and pancreas, it is up-regulated during monocyte maturation. Multiple transcript variants encoding different isoforms have been found.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ASAP2
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene ASAP2
Gene Accession No. O43150
Gene Alias 6530401G17Rik; AMAP2; Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2; ArfGAP with SH3 domain, ankyrin repeat and PH domain 2; Asap2; centaurin, beta 3; CENTB3; DDEF2; development and differentiation enhancing factor 2; development and differentiation-enhancing factor 2; Gm1523; Gm592; KIAA0400; PAG3; PAP; Pap-alpha; PAPbeta; Paxillin-associated protein with ARF GAP activity 3; PYK2 C terminus-associated protein; pyk2 C-terminus-associated protein; SHAG1
Gene Symbols ASAP2
Host Species Rabbit
Immunogen Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 691-763. Recombinant protein control fragment (Product #RP-109959).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8853
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Format Liquid
Isotype IgG
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