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Invitrogen™ ASAP2 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA523345
Description
ASAP2 Polyclonal Antibody for Western Blot
ASAP2 is a multidomain protein belonging to the beta family with two ANK repeats, an Arf-GAP domain, a PH domain and a SH3 domain. This protein localizes in the Golgi apparatus and also at the plasma membrane where it colocalizes with protein tyrosine kinase 2-beta (PYK2) and forms a stable complex with PYK2 in vivo. ASAP2 is tyrosine phosphorylated by activated PYK2. It functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. ASAP2 activates the small GTPases ARF1, ARF5 and ARF6 and regulates the formation of post-Golgi vesicles and modulates constitutive secretion. It modulates phagocytosis mediated by Fc gamma receptor and ARF6. Usually detected in heart, brain, placenta, kidney, monocytes and pancreas, it is up-regulated during monocyte maturation. Multiple transcript variants encoding different isoforms have been found.
Specifications
ASAP2 | |
Polyclonal | |
Unconjugated | |
ASAP2 | |
6530401G17Rik; AMAP2; Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2; ArfGAP with SH3 domain, ankyrin repeat and PH domain 2; Asap2; centaurin, beta 3; CENTB3; DDEF2; development and differentiation enhancing factor 2; development and differentiation-enhancing factor 2; Gm1523; Gm592; KIAA0400; PAG3; PAP; Pap-alpha; PAPbeta; Paxillin-associated protein with ARF GAP activity 3; PYK2 C terminus-associated protein; pyk2 C-terminus-associated protein; SHAG1 | |
Rabbit | |
Protein A | |
RUO | |
211914, 362719, 8853 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Western Blot | |
0.5 mg/mL | |
PBS with 0.05% BSA and 0.05% sodium azide | |
O43150, Q7SIG6 | |
ASAP2 | |
A portion of amino acids 700-750 of human ASAP2. | |
100 μg | |
Primary | |
Human, Mouse, Rat, Monkey, Marsupial | |
Antibody | |
IgG |
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