Invitrogen™ ASCC2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA530849

Catalog No. PIPA530849

Description

Recommended positive controls: A549, HeLa, HepG2, HCT116. Predicted reactivity: Mouse (81%), Rat (82%), Bovine (80%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Plays a role in DNA damage repair as component of the ASCC complex. Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). [UniProt].

Specifications

• Antigen: ASCC2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ASCC2
• Gene Alias: 1700011I11Rik; 2610034L15Rik; activating signal cointegrator 1 complex subunit 2; AI482016; ASC-1 complex subunit P100; Asc1p100; ASCC2; AW046480; p100; RGD1561422; trip4 complex subunit p100
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 84164
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q9H1I8
• Gene Symbols: ASCC2
• Immunogen: Recombinant protein encompassing a sequence within the center region of human ASCC2. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG