Invitrogen™ ASCL1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA585754

Catalog No. PIPA585754

Description

Keep as concentrated solution. Predicted reactivity: Mouse (100%), Rat (100%). Positive Control: SH-SY5Y, SH-SY5Y nuclear extract. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

ASCL1 (also known as ASH1) is a basic helix-loop-helix transcription factor that is required for early development of the nervous system. Expressed in fetal brain, ASCL1 is essential for the proper development of autonomic neurons and for the survival of subsets of autonomic neurons. ASCL1 interaction with MEF-2A may regulate the expression of specific genes that are critical for the formation of distinct neuronal circuits within the central nervous system. The high level of ASCL1 expression in neuroendocrine tumors, such as medullary thyroid cancer, small cell lung cancer and lung cancer with neuroendocrine features may provide a useful marker for cancers with neuroendocrine features. Mapping to human chromosome 12, the ASCL1 gene contains a trinucleotide repeat region, making this locus a candidate for inherited disease.

Specifications

• Antigen: ASCL1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Ascl1
• Gene Alias: achaete scute protein; achaete-scute complex homolog 1; achaete-scute complex homolog 1 (Drosophila); achaete-scute complex homolog-like 1; achaete-scute complex-like 1; achaete-scute complex-like protein 1; achaete-scute family bHLH transcription factor 1; achaete-scute homolog 1; AI225900; Ascl1; ASH1; ASH-1; bHLHa46; Class A basic helix-loop-helix protein 46; HASH1; KMT2H; mammalian achaete scute homolog 1; Mash1; mASH-1
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 17172, 429, 64186
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 0.62 mg/mL
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: P19359, P50553, Q02067
• Gene Symbols: Ascl1
• Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of mouse ASCL1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov