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Invitrogen™ ASGR1 Polyclonal Antibody
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Catalog No. PIPA589131
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100 μL
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PIPA589131 100 μL
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Catalog No. PIPA589131 Supplier Invitrogen™ Supplier No. PA589131
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Description

Rabbit Polyclonal Antibody

Positive Samples: HepG2, 22Rv1, SW620, Mouse liver, Mouse lung, Mouse testis, Rat liver, Rat lung, Rat testis; Cellular Location: Membrane, Single-pass type II membrane protein Immunogen sequence: QNSQLQEELR GLRETFSNFT ASTEAQVKGL STQGGNVGRK MKSLESQLEK QQKDLSEDHS SLLLHVKQFV SDLRSLSCQM AALQGNGSER TCCPVNWVEH ERSCYWFSRS GKAWADADNY CRLEDAHLVV VTSWEEQKFV QHHIGPVNTW MGLHDQNGPW KWVDGTDYET GFKNWRPEQP DDWYGHGLGG GEDCAHFTDD GRWNDDVCQR PYRWVCETEL DKASQEPPLL.

The asialoglycooprotein receptor (ASGPR) is a transmembrane glycoprotein (42 kDa) which mediates binding, internalization and degradation of extracellular glycoproteins that have exposed terminal galactose residues. The receptor is expressed on the surface of the hepatocytes in a polar manner, i. e. it is present on the sinusoidal and lateral plasma membranes but not on the bile canalicular membrane. The mammalian hepatic ASGPR mediate the endocytosis and degradation of serum proteins from which terminal sialic residues have been removed. The rat asialoglycoprotein receptor (ASGPR) consists of three polypeptide subunits: rat hepatic lectin (RHL)-1, RHL-2 and RHL-3. The monoclonal antibody 8D7 recognizes a subunit-specific epitope of RHL-1 of rat ASGPR. The monoclonal antibody 8D7 is cross reactive with human ASGPR.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ASGR1
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 3.38 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Asgr1
Gene Accession No. P02706, P07306, P34927
Gene Alias ASGPR; ASGPR 1; ASGP-R 1; ASGPR1; ASGR; ASGR1; Asgr-1; asialoglycoprotein receptor (RHL1); asialoglycoprotein receptor 1; Asialoglycoprotein receptor 1 (hepatic lectin); asialoglycoprotein receptor RHL1; CLEC4H1; C-type lectin domain family 4 member H1; Hepatic lectin 1; hepatic lectin 1 RHL1; hepatic lectin 1, RHL1; hepatic lectin H1; HL-1; RATRHL1; RHL1; RHL-1; Unknown (protein for MGC:133691)
Gene Symbols Asgr1
Host Species Rabbit
Immunogen Recombinant protein (or fragment).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11889, 24210, 432
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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