Invitrogen™ ASIC1 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA5143225

Catalog No. PIPA5143225

Description

Additional Information: This antibody is expected to recognize all reported isoforms (NP_064423.2; NP_001086.2; NP_001243759.1). This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is expressed in most if not all brain neurons, and it may be an ion channel subunit; however, its function as an ion channel remains unknown. Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. ASIC1 is permeable for Ca(2+), Li(+) and K(+) and is expressed in dorsal root ganglia, sciatic nerves, olfactory bulb, neo and allocortical regions, dentate granule cells, pyramidal cells of CA1-CA3 subfields of the hippocampal formation, habenula, basolateral amygdaloid nuclei, and in the Purkinje and granule cells of the cerebellum. It is diffusely detected over most other regions of the basal ganglia, including thalamic nuclei, substantia nigra, striatum and globus pallidus, hypothalamus, midbrain, pons, medulla and choroid plexus. Isoform 3 is expressed only in dorsal root ganglion while isoform 1 is expressed in DRG, spinal chord, trigeminal ganglia and the trigeminal mesencephalic nucleus.

Specifications

• Antigen: ASIC1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ASIC1
• Gene Alias: Accn2; ACCN2 variant 3; acid sensing (proton gated) ion channel 1; acid sensing ion channel; acid sensing ion channel 1; acid sensing ion channel subunit 1; acid-sensing (proton-gated) ion channel 1; Acid-sensing ion channel; Acid-sensing ion channel 1; acid-sensing ion channel 1a protein; AI843610; Amiloride-sensitive cation channel 2, neuronal; Asic; ASIC1; ASIC1a; B530003N02Rik; BNAC2; brain sodium channel 2; Cation channel, amiloride-sensitive, neuronal, 2; degenerin 2; hBNaC2; proton gated cation channel ASIC1
• Host Species: Goat
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 11419, 41
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P78348, Q6NXK8
• Gene Symbols: ASIC1
• Immunogen: Peptide with sequence C-NILPHHPARGT.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG