Invitrogen™ ASIC1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA526278

Catalog No. PIPA526278

Description

This antibody is predicted to react with chicken, mouse and rat based on sequence homology.

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is expressed in most if not all brain neurons, and it may be an ion channel subunit; however, its function as an ion channel remains unknown. Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. ASIC1 is permeable for Ca(2+), Li(+) and K(+) and is expressed in dorsal root ganglia, sciatic nerves, olfactory bulb, neo and allocortical regions, dentate granule cells, pyramidal cells of CA1-CA3 subfields of the hippocampal formation, habenula, basolateral amygdaloid nuclei, and in the Purkinje and granule cells of the cerebellum. It is diffusely detected over most other regions of the basal ganglia, including thalamic nuclei, substantia nigra, striatum and globus pallidus, hypothalamus, midbrain, pons, medulla and choroid plexus. Isoform 3 is expressed only in dorsal root ganglion while isoform 1 is expressed in DRG, spinal chord, trigeminal ganglia and the trigeminal mesencephalic nucleus.

Specifications

• Antigen: ASIC1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ASIC1
• Gene Alias: Accn2; ACCN2 variant 3; acid sensing (proton gated) ion channel 1; acid sensing ion channel; acid sensing ion channel 1; acid sensing ion channel subunit 1; acid-sensing (proton-gated) ion channel 1; Acid-sensing ion channel; Acid-sensing ion channel 1; acid-sensing ion channel 1a protein; AI843610; Amiloride-sensitive cation channel 2, neuronal; Asic; ASIC1; ASIC1a; B530003N02Rik; BNAC2; brain sodium channel 2; Cation channel, amiloride-sensitive, neuronal, 2; degenerin 2; hBNaC2; proton gated cation channel ASIC1
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography, Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 41
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.33 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene Accession No.: P78348
• Gene Symbols: ASIC1
• Immunogen: KLH conjugated synthetic peptide between 500-526 amino acids from the C-terminal region of human ACCN2.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG