Invitrogen™ ASIC2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA587945

Catalog No. PIPA587945

Description

Immunogen sequence: NLQIPDPHLA DPSVLEALRQ KANFKHYKPK QFSMLEFLHR VGHDLKDMML YCKFKGQECG HQDFTTVFTK YGKCYMFNSG EDGKPLLTTV KGGTGNGLEI MLDIQQDEYL PIWGETEETT FEAGVKVQIH SQSEPPFIQE LGFGVAPGFQ TFVATQEQRL TYLPPPWGEC RSSEMGLDFF PVYSITACRI DCETRYIVEN CNCRMVHMPG DAPFCTPEQH KECAEPALGL LAEKDSNYCL CRTPCNLTRY NKELSMVKIP SKTSAKYLEK KFNKSEKYIS E; Positive Samples: U-251MG, 293T, Mouse brain, Rat brain, Rat lung; Cellular Location: Cell membrane, Multi-pass membrane protein.

ACCN1 encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this protein may play a role in neurotransmission. In addition, a heteromeric association between this member and ACCN3 (variant 1) has been observed to co-assemble into proton-gated channels sensitive to gadolinium.

Specifications

• Antigen: ASIC2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ASIC2
• Gene Alias: ACCN; ACCN1; ACIC2; acid sensing (proton gated) ion channel 2; acid sensing ion channel 2; acid sensing ion channel subunit 2; acid-sensing (proton-gated) ion channel 2; acid-sensing ion channel 2; Amiloride-sensitive brain sodium channel; amiloride-sensitive brain sodium channel 2; Amiloride-sensitive cation channel 1, neuronal; amiloride-sensitive cation channel 1, neuronal (degenerin); Amiloride-sensitive cation channel neuronal 1; Asic2; ASIC2a; Bnac1; BNaC1a; BNC1; BNC1k; Brain sodium channel 1; degenerin; hBNaC1; Mammalian degenerin homolog; MDEG; MDEG1; MDEG2; neuronal amiloride-sensitive cation channel 1
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11418, 25364, 40
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 5.58 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q16515, Q62962, Q925H0
• Gene Symbols: ASIC2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 120-400 of human ASIC2 (NP_0010852).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG