Invitrogen™ ASIC3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA541022

Catalog No. PIPA541022

Description

Peptide sequence: VATFLYQVAE RVRYYREFHH QTALDERESH RLIFPAVTLC NINPLRRSRL Sequence homology: Cow: 80%; Dog: 80%; Guinea Pig: 80%; Horse: 80%; Human: 100%; Mouse: 87%; Pig: 87%; Rabbit: 87%; Rat: 87%.

ACCN3 encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. ACCN3 encodes a member that is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and ACCN1 has been observed as proton-gated channels sensitive to gadolinium.

Specifications

• Antigen: ASIC3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ASIC3
• Gene Alias: ACCN3; acid sensing (proton gated) ion channel 3; acid sensing ion channel 3; acid sensing ion channel subunit 3; acid-sensing (proton-gated) ion channel 3; acid-sensing ion channel 3; Amiloride-sensitive cation channel 3; amiloride-sensitive cation channel 3, testis; Asic3; AW742291; dorsal root ASIC; DRASIC; hASIC3; hTNaC1; modulatory subunit of ASIC2a; neuronal amiloride-sensitive cation channel 3; proton gated cation channel DRASIC; proton-gated cation channel subunit; SLNAC1; Testis sodium channel 1; TNaC1
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 9311
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: Q9UHC3
• Gene Symbols: ASIC3
• Immunogen: Synthetic peptide directed towards the N-terminal of human ACCN3 (aa 53-102).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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