Invitrogen™ ASIC4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5119835

Catalog No. PIPA5119835

Description

Positive Control: HepG2 cell lysate, human brain tissue lysate, K562 cell lysate, rat brain tissue, mouse pituitary tissue, SH-SY5Y. Subcellular Location: Membrane.

This gene belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. These channels have been implicated in synaptic transmission, pain perception as well as mechanoperception. This gene is predominantly expressed in the pituitary gland, and was considered a candidate for paroxysmal dystonic choreoathetosis (PDC), a movement disorder, however, no correlation was found between mutations in this gene and PDC. Alternative splicing at this locus results in two transcript variants encoding different isoforms.

Specifications

• Antigen: ASIC4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Asic4
• Gene Alias: Accn4; acid sensing (proton gated) ion channel family member 4; acid sensing ion channel family member 4; acid sensing ion channel subunit family member 4; acid-sensing (proton-gated) ion channel family member 4; acid-sensing ion channel 4; Amiloride-sensitive cation channel 4; Amiloride-sensitive cation channel 4, pituitary; amiloride-sensitive cation channel family member 4, pituitary; ASIC4; BNAC4; brain sodium channel 4; MGC17248; MGC24860; putative acid-sensing ion channel; Spasic; Spinal chord ASIC
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 241118, 55515, 63882
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: TBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: Q7TNS7, Q96FT7, Q9JHS6
• Gene Symbols: Asic4
• Immunogen: Recombinant protein within human ASIC4 aa 250-450.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG