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ASK1 Polyclonal Antibody, Invitrogen™

Catalog No. 01674178
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Catalog No. Quantity
01-674-178 100 μg
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Catalog No. 01-674-178 Supplier Thermo Scientific Supplier No. PA112518

Description

Rabbit Polyclonal Antibody

A suggested positive control for this product is SW1353 whole cell lysate.

MAP3K5 (ASK1) is a serine/threonine kinase that is abundantly expressed in human heart and pancreas and are activated in response to various extracellular stimuli, including cytokines, growth factors and environmental stresses. A novel MAP kinase kinase kinase (MAPKKK) was identified and designated ASK1 (for apoptosis signal-regulating kinase 1) and MAPKKK5. ASK1 activates two different subgroups of MAPKK, MKK4 and MKK6, which in turn activates c-Jun N-terminal kinase (JNK) and p38 MAP kinase, respectively. ASK1/MAPKKK5 is activated by TNFR and Fas through the interaction with members of the TRAF family and Fas-associated protein Daxx. Overexpression of ASK1 induced apoptotic cell death and a catalytically inactive form of ASK1 inhibited TNF-a-induced apoptosis. ASK1 is expressed in variety of human and mouse tissues.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ASK1
Applications Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene MAP3K5
Gene Accession No. Q99683
Gene Alias 7420452D20Rik; apoptosis signal regulating kinase 1; apoptosis signal-regulating kinase 1; ASK; ASK 1; ASK1; ASK-1; EC 2.7.11.25; kinase ASK1; M3K5; MAP/ERK kinase kinase 5; Map3k5; MAPK/ERK kinase kinase 5; MAPKKK5; MEK kinase 5; MEKK 5; Mekk5; mitogen activated protein kinase kinase kinase 5; mitogen-activated protein kinase kinase kinase 5; RGD1306565; RP3-325F22.4
Gene Symbols MAP3K5
Host Species Rabbit
Immunogen Synthetic peptide corresponding to residues 1356-1375 of human ASK1.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4217
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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