Invitrogen™ ASL Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA522300

Catalog No. PIPA522300

Description

Recommended positive controls: HeLa, HepG2, Neuro2A, GL261, C8D30, NIH-3T3, BCL-1, Raw264.7, C2C12. Predicted reactivity: Mouse (93%), Rat (88%), Bovine (95%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

ASL encodes a member of the lyase 1 family. The encoded protein forms a cytosolic homotetramer and primarily catalyzes the reversible hydrolytic cleavage of argininosuccinate into arginine and fumarate, an essential step in the liver in detoxifying ammonia via the urea cycle. Mutations in this gene result in the autosomal recessive disorder argininosuccinic aciduria, or argininosuccinic acid lyase deficiency. A nontranscribed pseudogene is also located on the long arm of chromosome 22. Alternatively spliced transcript variants encoding different isoforms have been described.

Specifications

• Antigen: ASL
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ASL
• Gene Alias: 2510006M18Rik; argininosuccinase; argininosuccinate lyase; Arginosuccinase; ASAL; Asl
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 109900, 435
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.78 mg/mL
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: P04424, Q91YI0
• Gene Symbols: ASL
• Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 13 and 261 (P04424) of ASL.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG