Invitrogen™ ASL Polyclonal Antibody

Catalog No.	Quantity
PIPA5120992	100 μL

Catalog No. PIPA5120992 Supplier Invitrogen™ Supplier No. PA5120992

Description

Rabbit Polyclonal Antibody

Positive test controls include: HeLa, HepG2, SH-SY5Y, Mouse liver, Mouse brain, Mouse kidney, Rat liver. Immunogen sequence: NPDSLELIRS KAGRVFGRCA GLLMTLKGLP STYNKDLQED KEAVFEVSDT MSAVLQVATG VISTLQIHQE NMGQALSPDM LATDLAYYLV RKGMPFRQAH EASGKAVFMA ETKGVALNQL SLQELQTISP LFSGDVICVW DYGHSVEQYG ALGGTARSSV DWQIRQVRAL LQAQQA.

ASL encodes a member of the lyase 1 family. The encoded protein forms a cytosolic homotetramer and primarily catalyzes the reversible hydrolytic cleavage of argininosuccinate into arginine and fumarate, an essential step in the liver in detoxifying ammonia via the urea cycle. Mutations in this gene result in the autosomal recessive disorder argininosuccinic aciduria, or argininosuccinic acid lyase deficiency. A nontranscribed pseudogene is also located on the long arm of chromosome 22. Alternatively spliced transcript variants encoding different isoforms have been described.

Specifications

• Antigen: ASL
• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.84 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
• Gene: ASL
• Gene Accession No.: P04424, P20673, Q91YI0
• Gene Alias: 2510006M18Rik; argininosuccinase; argininosuccinate lyase; Arginosuccinase; ASAL; Asl
• Gene Symbols: ASL
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 289-464 of human ASL (NP_000039.2).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 109900, 435, 59085
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG