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Tocris Bioscience™ ASP 3026

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Quantity:
10 mg
50 mg
Description
ASP 3026 is a potent anaplastic lymphoma kinase (ALK) inhibitor (IC50 = 3.5 nM). Also inhibits Ack and ROS1 activity (IC50 values are 5.8 and 8.9 nM respectively). Attenuates proliferation, and induces apoptosis of NPM-ALK+ T cell anaplastic large-cell lymphoma (ALCL) cells in vitro. Suppresses tumor growth of NPM-ALK+ ALCL cell xenografts in mice. Causes tumor shrinkage in hEML4-ALK transgenic mice. Orally available.
Specifications
Specifications
Chemical Name or Material | N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine |
CAS | 1097917-15-1 |
Quantity | 50 mg |
Target | ALK Inhibitors |
Molecular Formula | C29H40N8O3S |
Formula Weight | 580.74 |
Purity | >99% |
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