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R&D Systems™ ASP 7967
SDP

Catalog No. RD10188012 Shop All Novus Products
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RD10188012 50 mg
RD10188002 10 mg
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Catalog No. RD10188012 Supplier R&D Systems™ Supplier No. 8803/50

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Description

A Tocris product, part of R&D Systems. Ligand for RNA aptamer AC17-4 activating gene expression in aptazime-based riboswitches

ASP 7967 is a ligand for RNA aptamer AC17-4 that activates gene expression in synthetic aptazime-based riboswitches at as low as 5 μM concentration, without relying on exogenous protein factors. ASP 7967 binds aptamer AC17-4 with high affinity in HEK293 cells (Kd = 12 nM; EC50 = 2.3 μM), activating gene expression (>10-fold) in HEK293 cells. ON/OFF ratio of riboswitches activated by ASP 7967 approaches 300, with a low basal expression level in cultured cells.

In vivo, ASP 7967 upregulates the serum hEPO concentration by 7.2-fold over the vehicle control (mice). Cell permeable and low-toxic, ASP 7967 is orally bioavailable.

Specifications

Chemical Name or Material N2,N4-Bis(4-fluorophenyl)-N6-(2-pyrimidinylmethyl)-1,3,5-triazine-2,4,6-triamine hemifumarate
CAS 1246958-42-8
Quantity 50 mg
Product Line Tocris
Target DNA, RNA and Protein Synthesis Compounds
Molecular Formula C20H16F2N8.½C4H4O4
Purity 98%
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