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Tocris Bioscience™ Astemizole

Catalog No. 348950
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Quantity:
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Orally active, potent H1 antagonist. Also KV11.1 (hERG) channel blocker

Orally active, potent histamine H1 antagonist (IC50 = 4 nM) that displays 20-fold, > 250-fold and > 250-fold selectivity over 5-HT, dopamine and muscarinic acetylcholine receptors respectively. Exhibits antimalarial activity in multidrug resistant strains in vitro (IC50 = 227 - 734 nM). Also potent KV11.1 (hERG) channel blocker (IC50 = 0.9 nM) that displays cardiotoxicity in vivo.

Chemical Identifiers

CAS 68844-77-9
Molecular Formula C28H31FN4O

Specifications

Quantity 50 mg
Formula Weight 458.57
Purity >99%
Molecular Weight (g/mol) 458.581
Chemical Name or Material Astemizole

Safety and Handling

Recommended Storage Store at +4°C
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