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Tocris Bioscience™ AT 7867
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Catalog No. 700150
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Catalog No. Quantity
70-015-0 50 mg
70-011-0 10 mg
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Catalog No. 70-015-0 Supplier Tocris Bioscience™ Supplier No. 7001/50
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Description

Potent pan-Akt and PKA inhibitor

AT 7867 is a potent pan-Akt (protein kinase B) and protein kinase A (PKA) inhibitor (IC50 values are 32, 17, 47 and 20 nM for Akt1, Akt2, Akt3 and PKA, respectively). Also inhibits p70-S6 kinase (p70S6K, IC50 = 85 nM). Inhibits Akt signaling and proliferation of multiple human cancer cell lines, including breast, prostate and colon. Promotes proliferation of iPSC-derived PDX1+ pancreatic progenitor cells (PPCs).

Specifications

Chemical Name or Material 4-(4-Chlorophenyl)-4-[4-(1 H-pyrazol-4-yl)phenyl]piperidine hydrochloride
Quantity 50 mg
Target Akt (Protein Kinase B) Inhibitors
Molecular Formula C20H20ClN3.HCl
Purity 0.98
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