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Invitrogen™ Ataxin 1 Monoclonal Antibody (2B13G8)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA549210

Catalog No. PIMA549210


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Description

Description

Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL. Immunogen sequence is different from the related and rat sequences by one amino acid. Positive Control - WB: human HepG2 whole cell, human 293T whole cell, human A431 whole cell, human PC-3 whole cell, rat brain tissue, rat liver tissue, mouse brain tissue, mouse liver tissue. IHC: human hepatocellular carcinoma tissue, human laryngeal squamous cell carcinoma tissue, human thyroiditis tissue, mouse brain tissue, rat cerebellum tissue. Flow: PC-3 cell, ANA-1 cell, NRK cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the pure cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 41-81 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1). At least two transcript variants encoding the same protein have been found for this gene.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Ataxin 1
Monoclonal
500 μg/mL
PBS with 4mg trehalose and no preservative
P54253, P54254, Q63540
ATXN1
A synthetic peptide corresponding to a sequence at the C-terminus of human Ataxin 1(778-808aa ESRKLEKSEDEPPLTLPKPSLIPQEVKICIE).
100 μg
Primary
Human, Mouse, Rat
Antibody
IgG2b
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
2B13G8
Unconjugated
ATXN1
2900016G23Rik; alternative ataxin1; ataxin 1; Ataxin1; ataxin-1; Atx1; Atx-1; Atx-1-PB; Atxn1; C85907; CG4547; CG4547-PB; D6S504E; dAtx-1; Dmel\CG4547; Dmel_CG4547; ENSMUSG00000074917; Gm10786; OTTHUMP00000016065; SCA1; spinocerebellar ataxia 1; spinocerebellar ataxia 1 homolog; spinocerebellar ataxia type 1 protein; Spinocerebellar ataxia type 1 protein homolog
Mouse
Antigen affinity chromatography
RUO
20238, 25049, 6310
-20°C
Lyophilized
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