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Invitrogen™ Ataxin 3 Polyclonal Antibody
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Catalog No. PIPA5114885
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PIPA5114885 100 μL
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Catalog No. PIPA5114885 Supplier Invitrogen™ Supplier No. PA5114885
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total Ataxin 3.

Machado-Joseph disease is an autosomal dominant neurologic disorder, and is now known to be the same as previously described spinocerebellar ataxia-3. MJD protein (Ataxin-3) contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is the cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. This protein interacts with key regulators (CBP, p300 and PCAF) of transcription and represses transcription, and also acts as a histone-binding protein that regulates transcription. MJD is a deubiquitinating enzyme.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Ataxin 3
Applications Immunohistochemistry (PFA fixed), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene ATXN3
Gene Accession No. O35815, P54252, Q9CVD2
Gene Alias 2210008M02Rik; AI463012; AI647473; AT3; ataxin 3; ataxin 3 variant an; ataxin 3 variant ao; ataxin 3 variant at; ataxin 3 variant e; ataxin 3 variant h; ataxin 3 variant m; ataxin 3 variant r; ataxin 3 variant ref; ataxin 3 variant y; ataxin3; ataxin-3; ATX3; ATXN3; JOS; josephin; Machado-Joseph disease (spinocerebellar ataxia 3, olivopontocerebellar ataxia 3, autosomal dominant, ataxin 3); Machado-Joseph disease (spinocerebellar ataxia 3, olivopontocerebellar ataxia 3, autosomal dominant, ataxin 3) homolog; Machado-Joseph disease protein 1; Machado-Joseph disease protein 1 homolog; MJD; MJD1; olivopontocerebellar ataxia 3; Rsca3; Sca3; spin; Spinocerebellar ataxia type 3 protein
Gene Symbols ATXN3
Host Species Rabbit
Immunogen A synthesized peptide derived from human ATXN3(Accession P54252), corresponding to amino acid residues Q230-E280.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 110616, 4287, 60331
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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