Ataxin 3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA578847

Catalog No. PIPA578847

Description

The synthetic peptide sequence is 226-254aa, EEDLQRALALSRQEIDMEDEEADLRRAIQ Add 0.2 mL of distilled water, will yield a concentration of 500 μg/mL.

Machado-Joseph disease is an autosomal domit neurologic disorder, and is now known to be the same as previously described spinocerebellar ataxia-3. MJD protein (Ataxin-3) contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is the cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. This protein interacts with key regulators (CBP, p300 and PCAF) of transcription and represses transcription, and also acts as a histone-binding protein that regulates transcription. MJD is a deubiquitinating enzyme.

Specifications

• Antigen: Ataxin 3
• Classification: Polyclonal
• Formulation: PBS with 5MG BSA, 5MG BSA and 0.05MG sodium azide, 0.05MG sodium azide, 0.05MG thimerosal, 0.05MG thimerosal
• Gene Accession No.: O35815, P54252, Q9CVD2
• Gene Symbols: ATXN3
• Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human Ataxin 3.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Gene: ATXN3
• Gene Alias: Ataxin-3, Machado-Joseph disease protein 1, Spinocerebellar ataxia type 3 protein, ATXN3, ATX3, MJD, MJD1, SCA3
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 110616, 4287, 60331
• Content And Storage: -20°C
• Form: Lyophilized