Invitrogen™ Ataxin 7 Monoclonal Antibody (3SCA-1C1)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA3083

Catalog No. PIMA3083

Description

MA3-083 detects Ataxin 7 from human and mouse samples. MA3-083 has been successfully used in Western blot, immunofluorescence, and ELISA applications. The MA3-083 epitope is mapped between aa 66 and aa 119.

Spinocerebellar ataxia type 7 (SCA7) belongs to a class of hereditary neurodegenrative diseases characterized by abnormally expanded polyglutamine (CAG) repeats at the N-terminus. This autosomal dominant cerebellar ataxia primarily affects the cerebellum, retina, and brain stem and causes dementia, macular degeneration and other neurodegenerative characteristics. SCA7 gene encodes the ubiquitous 892 residue protein ataxin-7. This protein is typically located in the cytoplasm and on the nuclear membrane of normal brain neurons. In cells where there is a mutation of the SCA7 gene, ataxin 7 accumulates in intranuclear inclusions and can result in cell death.

Specifications

• Antigen: Ataxin 7
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: Ascites with 0.05% sodium azide
• Gene Accession No.: O15265, Q8R4I1
• Gene Symbols: ATXN7
• Immunogen: Recombinant human Ataxin 7 aa 1 - 229.
• Regulatory Status: RUO
• Gene ID (Entrez): 246103, 6314
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Clone: 3SCA-1C1
• Conjugate: Unconjugated
• Gene: ATXN7
• Gene Alias: A430107N12Rik; ADCAII; AI627028; Ataxin 7; Ataxin7; Ataxin-7; ATXN7; Atxn7-PA; Atxn7-PB; Atxn7-PC; Atxn7-PD; CG9866; CG9866-PA; CG9866-PB; CG9866-PC; CG9866-PD; Dmel\CG9866; Dmel_CG9866; LD40170p; OPCA3; RGD1562692; SCA7; spinocerebellar ataxia 7 homolog; spinocerebellar ataxia type 7 protein; Spinocerebellar ataxia type 7 protein homolog
• Host Species: Mouse
• Quantity: 50 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG1 κ