Invitrogen™ ATF1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA541490

Catalog No. PIPA541490

Description

Peptide sequence: KNREAARECR RKKKEYVKCL ENRVAVLENQ NKTLIEELKT LKDLYSNKSV Sequence homology: Cow: 100%; Dog: 93%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 93%; Sheep: 77%; Zebrafish: 100%.

This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6.

Specifications

• Antigen: ATF1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ATF1
• Gene Alias: AATase 1; Activating transcription factor 1; alcohol O-acetyltransferase; Alcohol O-acetyltransferase 1; ATF1; Atf-1; cAMP-dependent transcription factor ATF-1; cyclic AMP-dependent transcription factor ATF-1; EWS-ATF1; FUS/ATF-1; Protein TREB36; TCR-ATF1; TREB36; Unknown (protein for MGC:64099); wu:fc92c07; YOR377W; zgc:64099
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 466
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: P18846
• Gene Symbols: ATF1
• Immunogen: Synthetic peptide directed towards the C-terminal of human ATF1 (aa 222-271).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG