Invitrogen™ ATF4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120026

Catalog No. PIPA5120026

Description

Positive test controls include: HeLa. The target is usually found in the following locations: Cell membrane, Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center. Immunogen sequence: MTEMSFLSSE VLVGDLMSPF DQSGLGAEES LGLLDDYLEV AKHFKPHGFS SDKAKAGSSE WLAVDGLVSP SNNSKEDAFS GTDWMLEKMD LKEFDLDALL GIDDLETMPD DLLTTLDDTC DLFAPLVQET NKQPPQTVNP IGHLPESLTK PDQVAPFTFL QPLPLSPGVL SSTPDHSFSL ELGSEVDITE GDRKPDYTAY VAMIPQCIKE EDTPSDNDSG ICMSPESYLG SPQHSPSTRG SPNRSLPSPG VLCGSARPKP YDPPGEKMVA AKVKGEKLDK KLKKMEQNKT AATRYRQKKR AEQEALTGEC KELEKKNEAL KERADSLAKE IQYLKDLIEE VRKARGKKRV P.

This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromsome at q28 in a region containing a large inverted duplication.

Specifications

• Antigen: ATF4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Atf4
• Gene Alias: Activating transcription factor 4; activating transcription factor 4 (tax-responsive enhancer element B67); activating transcription factor 4a; activating transcription factor 4b1 (tax-responsive enhancer element B67); activating transcription factor ATF-4; ATF 4; atf4; Atf-4; atf4 {ECO:0000312; ATF4 protein; atf4a; atf4b1; C/ATF; C/EBP-related ATF; cAMP response element-binding protein 2; cAMP-dependent transcription factor ATF-4; cAMP-responsive element-binding protein 2; CREB 2; CREB2; CREB-2; Cyclic AMP-dependent transcription factor ATF-4; cyclic AMP-responsive element-binding protein 2; DNA-binding protein TAXREB67; hypothetical protein LOC509107; OTTHUMP00000199130; rATF-4; RGD:621863}; tax-re; TaxREB67; TaxREB67 homolog; tax-responsive enhancer element B67; tax-responsive enhancer element-binding protein 67; Tax-responsive enhancer element-binding protein 67 homolog; TXREB; wu:fj01c08; wu:fk30b04; zgc:85951
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 468
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 0.44 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P18848
• Gene Symbols: Atf4
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-351 of human ATF4 (NP_001666.2).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG