Invitrogen™ ATF5 Recombinant Rabbit Monoclonal Antibody (9D8)

Catalog No.	Quantity
PIMA538303	100 μL

Catalog No. PIMA538303 Supplier Invitrogen™ Supplier No. MA538303

Description

Rabbit Recombinant Monoclonal Antibody

This antibody has been tested in direct-ELISA.

ATF5 is a protein coding gene. Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), ATF5-specific response element (ARE) (consensus: 5'-C[CT]TCT[CT]CCTT[AT]-3') but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation. Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4. Important regulator of the cerebral cortex formation, functions in cerebral cortical neuroprogenitor cells to maintain proliferation and to block differentiation into neurons. Must be down-regulated in order for such cells to exit the cycle and differentiate. Participates in the pathways by which SHH promotes cerebellar granule neuron progenitor cells proliferation. Critical for survival of mature olfactory sensory neurons (OSN), directs expression of OSN-specific genes. May be involved in osteogenic differentiation. Promotes cell proliferation and survival by inducing the expression of EGR1 sinergistically with ELK1. Once acetylated by EP300, binds to ARE sequences on target genes promoters, such as BCL2 and EGR1. Plays an anti-apoptotic role through the transcriptional regulation of BCL2, this function seems to be cell type-dependent. Cooperates with NR1I3/CAR in the transcriptional activation of CYP2B6 in liver. In hepatic cells, represses CRE-dependent transcription and inhibits proliferation by blocking at G2/M phase. May act as a negative regulator of IL1B transduction pathway in liver. Upon IL1B stimulus, cooperates with NLK to activate the transactivation activity of C/EBP subfamily members. Besides its function of transcription factor, acts as a cofactor of CEBPB to activate CEBPA and promote adipocyte differentiation. Regulates centrosome dynamics in a cell-cycle- and centriole-age-dependent manner. Forms 9-foci symmetrical ring scaffold around the mother centriole to control centrosome function and the interaction between centrioles and pericentriolar material.

Specifications

• Antigen: ATF5
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Recombinant Monoclonal
• Clone: 9D8
• Concentration: 1.2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.05% BSA, 50% glycerol, 150mM NaCl and 0.02% sodium azide; pH 7.4
• Gene: Atf5
• Gene Accession No.: Q6P788, Q9Y2D1
• Gene Alias: activating transcription factor 5; Activating transcription factor 5-alpha/beta; activating transcription factor 7; activating transcription factor X; AFTA; ATF5; Atf7; Atfx; BZIP protein ATF7; cAMP-dependent transcription factor ATF-5; Cyclic AMP-dependent transcription factor ATF-5; FLJ34666; HMFN0395; NAP1; NRIF3-associated protein; ODA-10; Transcription factor ATFx; transcription factor-like protein ODA-10
• Gene Symbols: Atf5
• Host Species: Rabbit
• Immunogen: A synthesized peptide derived from human ATF5.
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 22809, 282840
• Target Species: Human, Rat
• Content And Storage: -20°C or -80°C if preferred
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov