Invitrogen™ ATF6-beta Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA540399

Catalog No. PIPA540399

Description

Peptide sequence: FNRTESLRLA DELSGWVQRH QRGRRKIPQR AQERQKSQPR KKSPPVKAVP Sequence homology: Cow: 86%; Dog: 93%; Horse: 93%; Human: 100%; Mouse: 86%; Pig: 85%; Rat: 86%.

ATF6 beta(CREBL1) is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. ATF6 beta is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. The protein encoded by this gene bears sequence similarity with the Creb/ATF subfamily of the bZip superfamily of transcription factors. It localizes to both the cytoplasm and the nucleus. The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6.

Specifications

• Antigen: ATF6-beta
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Atf6b
• Gene Alias: AA617266; Activating transcription factor 6 beta; ATF6B; ATF6beta; ATF6-beta; cAMP response element binding protein-related protein; cAMP response element-binding protein-related protein; cAMP responsive element binding protein-like 1; cAMP-dependent transcription factor ATF-6 beta; cAMP-responsive element-binding protein-like 1; CREBL1; Creb-related protein; Creb-rp; cyclic AMP-dependent transcription factor ATF-6 beta; FLJ10066; G13; Processed cyclic AMP-dependent transcription factor ATF-6 beta; Protein G13
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1388
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: Q99941
• Gene Symbols: Atf6b
• Immunogen: Synthetic peptide directed towards the middle region of human CREBL1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov