Invitrogen™ ATF6-beta Polyclonal Antibody

Catalog No.	Quantity
PIPA599233	100 μL

Catalog No. PIPA599233 Supplier Invitrogen™ Supplier No. PA599233

Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total ATF6B.

ATF6 beta(CREBL1) is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. ATF6 beta is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. The protein encoded by this gene bears sequence similarity with the Creb/ATF subfamily of the bZip superfamily of transcription factors. It localizes to both the cytoplasm and the nucleus. The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6.

Specifications

• Antigen: ATF6-beta
• Applications: Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene: Atf6b
• Gene Accession No.: Q99941
• Gene Alias: AA617266; Activating transcription factor 6 beta; ATF6B; ATF6beta; ATF6-beta; cAMP response element binding protein-related protein; cAMP response element-binding protein-related protein; cAMP responsive element binding protein-like 1; cAMP-dependent transcription factor ATF-6 beta; cAMP-responsive element-binding protein-like 1; CREBL1; Creb-related protein; Creb-rp; cyclic AMP-dependent transcription factor ATF-6 beta; FLJ10066; G13; Processed cyclic AMP-dependent transcription factor ATF-6 beta; Protein G13
• Gene Symbols: Atf6b
• Host Species: Rabbit
• Immunogen: A synthesized peptide derived from human ATF6B(Accession Q99941), corresponding to amino acid residues L405-Q455.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1388
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG