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Invitrogen™ ATF6B Polyclonal Antibody
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Catalog No. PIPA5109425
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100 μL
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PIPA5109425 100 μL
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Catalog No. PIPA5109425 Supplier Invitrogen™ Supplier No. PA5109425
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MAELMLLSEI ADPTRFFTDN LLSPEDWGLQ NSTLYSGLDE VAEEQTQLFR CPEQDVPFDG SSLDVGMDVS.

ATF6 beta(CREBL1) is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. ATF6 beta is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. The protein encoded by this gene bears sequence similarity with the Creb/ATF subfamily of the bZip superfamily of transcription factors. It localizes to both the cytoplasm and the nucleus. The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ATF6B
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.76 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Atf6b
Gene Accession No. O35451
Gene Alias AA617266; Activating transcription factor 6 beta; ATF6B; ATF6beta; ATF6-beta; cAMP response element binding protein-related protein; cAMP response element-binding protein-related protein; cAMP responsive element binding protein-like 1; cAMP-dependent transcription factor ATF-6 beta; cAMP-responsive element-binding protein-like 1; CREBL1; Creb-related protein; Creb-rp; cyclic AMP-dependent transcription factor ATF-6 beta; FLJ10066; G13; Processed cyclic AMP-dependent transcription factor ATF-6 beta; Protein G13
Gene Symbols Atf6b
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human ATF6B (Q99941).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12915, 406169
Target Species Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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