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ATF7 Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Catalog No. 501562571
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50-156-2571 100 μL
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Catalog No. 50-156-2571 Supplier Bethyl Laboratories, Inc Supplier No. A302431A
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Orangutan

Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5′-GTGACGT[AG][AG]-3′), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family. Isoform 4/ATF-A0acts as a domit repressor of the E-selectin/NF-ELAM1/delta-A promoter. Isoform 5/ATF-4acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation. Gaire M., Nucleic Acids Res. 18:3467-3473(1990). Chatton B., Submitted (DEC-1990) to the EMBL/GenBank/DDBJ databases. Olsen J.V., Cell 127:635-648(2006).

Specifications

Antigen ATF7
Applications Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 1 mg/ml
Conjugate Unconjugated
Formulation phosphate, tris citrate with 0.09% sodium azide; pH 7-8
Gene ATF7
Gene Accession No. P17544
Gene Alias ATF7; ATFA; activating transcription factor 7; MGC57182
Gene Symbols ATF7
Host Species Rabbit
Immunogen Between 444 and 494
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11016
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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