ATF7 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA572585

Catalog No. PIPA572585

Description

Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5′-GTGACGT[AG][AG]-3′), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family. Isoform 4/ATF-A0acts as a domit repressor of the E-selectin/NF-ELAM1/delta-A promoter. Isoform 5/ATF-4acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation. Gaire M., Nucleic Acids Res. 18:3467-3473(1990). Chatton B., Submitted (DEC-1990) to the EMBL/GenBank/DDBJ databases. Olsen J.V., Cell 127:635-648(2006).

Specifications

• Antigen: ATF7
• Classification: Polyclonal
• Formulation: PBS with 0.09% sodium azide
• Gene Accession No.: P17544
• Gene Symbols: ATF7
• Immunogen: KLH conjugated synthetic peptide between 68-96 amino acids from the N-terminal region of human ATF7
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Western Blot
• Conjugate: Unconjugated
• Gene: ATF7
• Gene Alias: Cyclic AMP-dependent transcription factor ATF-7; cAMP-dependent transcription factor ATF-7; Activating transcription factor 7; Transcription factor ATF-A; ATF7; ATFA
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 11016
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid