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Invitrogen™ ATG101 Polyclonal Antibody
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Catalog No. PIPA5114272
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PIPA5114272 100 μL
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Catalog No. PIPA5114272 Supplier Invitrogen™ Supplier No. PA5114272
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: LLHRSTGKFH YKKEGTYSIG TVGTQDVDCD FIDFTYVRVS SEELDRALRK For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles. Predicted homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%.

ATG101 is involved in autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein ATG1. ATG101 is a recently discovered protein that stabilizes ATG13, another autophagy protein that forms a complex with the mammalian homologs of ATG1, ULK1 and ULK2, and with FIP200. This complex is a target of TOR phosphorylation under normal conditions inhibition of TOR by rapamycin or leucine deprivation leads to dephosphorylation of ATG13, ULK1 and ULK2, which then leads to autophagy. ATG101 also interacts with ULK1 and is essential for autophagy.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ATG101
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene ATG101
Gene Accession No. Q9BSB4
Gene Alias 9430023L20Rik; AA407441; ATG101; Atg13-interacting protein; AU022967; autophagy related 101; autophagy-related protein 101; C12orf44; PP894; RGD1359310
Gene Symbols ATG101
Host Species Rabbit
Immunogen Synthetic peptide directed towards the N-terminal region of Human C12orf44 (aa 29-78).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 60673
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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