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Invitrogen™ ATG12 Polyclonal Antibody
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Catalog No. PIPA517217
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100 μL
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PIPA517217 100 μL
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Catalog No. PIPA517217 Supplier Invitrogen™ Supplier No. PA517217
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Description

Rabbit Polyclonal Antibody

It is not recommended to aliquot this antibody.

ATG12, a member of the autophagy protein family, forms a conjugate with ATG5; this conjugate has a ubiquitin-protein ligase (E3)-like activity for protein lipidation in autophagy. This conjugate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells. ATG12 has also been shown to interact with ATG10 in human embryonic kidney cells in the presence of ATG7. At least two isoforms of ATG12 are known to exist. Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ATG12
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 3.4 μg/mL
Conjugate Unconjugated
Formulation 0.01M HEPES with 100 μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5
Gene ATG12
Gene Accession No. O94817
Gene Alias 4931423H11Rik; A330058M13Rik; APG 12; APG12; Apg12 (autophagy, yeast) homolog; APG12L; APG12-like; ATG12; ATG12 autophagy related 12 homolog; Atg12l; Atg12p; Atg12-PB; Autophagy protein 12-like; autophagy related 12; autophagy related protein 12; autophagy-related 12; autophagy-related protein 12; Autophagy-specific gene 12; CG10861; CG10861-PB; Dmel\CG10861; Dmel_CG10861; FBR93; HAPG12; IP05205p; IP05405p; OTTHUMP00000159129; ubiquitin-like protein ATG12; YBR1506; YBR217W
Gene Symbols ATG12
Host Species Rabbit
Immunogen Synthetic peptide corresponding to residues near the amino terminus of human Atg12.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9140
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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