Invitrogen™ ATG12 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA580360

Catalog No. PIPA580360

Description

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%). This antibody has specificity for Human ATG12.

ATG12, a member of the autophagy protein family, forms a conjugate with ATG5; this conjugate has a ubiquitin-protein ligase (E3)-like activity for protein lipidation in autophagy. This conjugate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells. ATG12 has also been shown to interact with ATG10 in human embryonic kidney cells in the presence of ATG7. At least two isoforms of ATG12 are known to exist. Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1.

Specifications

• Antigen: ATG12
• Classification: Polyclonal
• Formulation: PBS with no preservative
• Gene Accession No.: O94817
• Gene Symbols: ATG12
• Immunogen: A synthetic peptide corresponding to the N-terminus of the human ATG12.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot, Immunocytochemistry
• Conjugate: Unconjugated
• Gene: ATG12
• Gene Alias: 4931423H11Rik; A330058M13Rik; APG 12; APG12; Apg12 (autophagy, yeast) homolog; APG12L; APG12-like; ATG12; ATG12 autophagy related 12 homolog; Atg12l; Atg12p; Atg12-PB; Autophagy protein 12-like; autophagy related 12; autophagy related protein 12; autophagy-related 12; autophagy-related protein 12; Autophagy-specific gene 12; CG10861; CG10861-PB; Dmel\CG10861; Dmel_CG10861; FBR93; HAPG12; IP05205p; IP05405p; OTTHUMP00000159129; ubiquitin-like protein ATG12; YBR1506; YBR217W
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography, Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 9140
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid