ATG16L1 Monoclonal Antibody (OTI2A10), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA809571

Catalog No. 50-168-2890

Description

Autophagy related protein 16 L is encoded by the ATG16L gene and is located on chromosome 2 in humans. It is also known as WD30 or IBD10 (Inflammatory Bowel Disease 10). ATG 12 and ATG5 conjugate with each other and undergoes homo oligomerisation with ATG16L to form an 800 kDa complex called the Atg16L complex. This complex facilitates coupling or lipidation of LC3 to phosphatidylethanolamine (PE) and this ubiquitin-like conjugation system is a widely used marker for autophagy. However, the ATG 16L complex along with other ATGs like ATG 18 and ATG 21 prevent the premature cleavage of ATG8-PE by the cysteine protease, Atg4 until the autophagosome is deemed complete.

Specifications

• Antigen: ATG16L1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q676U5
• Gene Symbols: ATG16L1
• Immunogen: Human recombit protein fragment corresponding to amino acids 1-277 of human ATG16L produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: OTI2A10
• Conjugate: Unconjugated
• Gene: ATG16L1
• Gene Alias: APG16L, ATG16A, ATG16L, IBD10, WDR30
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55054
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid