ATG16L1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA118296

Catalog No. 01-670-549

Description

Reconstitute in 100 μL of sterile water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20 °C for a higher stability, and at 4 °C with an appropriate antibacterial agent. Avoid repetitive freeze/thaw cycles.

Autophagy related protein 16 L is encoded by the ATG16L gene and is located on chromosome 2 in humans. It is also known as WD30 or IBD10 (Inflammatory Bowel Disease 10). ATG 12 and ATG5 conjugate with each other and undergoes homo oligomerisation with ATG16L to form an 800 kDa complex called the Atg16L complex. This complex facilitates coupling or lipidation of LC3 to phosphatidylethanolamine (PE) and this ubiquitin-like conjugation system is a widely used marker for autophagy. However, the ATG 16L complex along with other ATGs like ATG 18 and ATG 21 prevent the premature cleavage of ATG8-PE by the cysteine protease, Atg4 until the autophagosome is deemed complete.

Specifications

• Antigen: ATG16L1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ATG16L1
• Gene Alias: 1500009K01Rik; A16L1; APG 16-L1; Apg16l; APG16L beta; APG16L isoforms 1; APG16-like 1; atg16; ATG16 autophagy related 16-like 1; ATG16A; Atg16l; Atg16l1; Atg16L1 gamma; autophagy related 16 like 1; autophagy related 16-like 1; autophagy related 16-like 1 (S. cerevisiae); autophagy-related 16-like 1; autophagy-related 16-like 1 gamma; autophagy-related protein 16-1; hCG_1817841; IBD10; UNQ9393/PRO34307; WD repeat domain 30; Wdr30
• Host Species: Rabbit
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Immunocytochemistry, Western Blot
• Concentration: Conc. Not Determined
• Formulation: whole serum with no preservative
• Gene Accession No.: Q676U5
• Gene Symbols: ATG16L1
• Immunogen: Synthetic peptide corresponding to the N-terminal residues of human ATG16-L1.
• Regulatory Status: RUO
• Gene ID (Entrez): 363278, 55054
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov