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Atg16L1 Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Catalog No. 501564766
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50-156-4766 100 μL
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Catalog No. 50-156-4766 Supplier Bethyl Laboratories, Inc Supplier No. A303294A
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Orangutan

Autophagy related protein 16 L is encoded by the ATG16L gene and is located on chromosome 2 in humans. It is also known as WD30 or IBD10 (Inflammatory Bowel Disease 10). ATG 12 and ATG5 conjugate with each other and undergoes homo oligomerisation with ATG16L to form an 800 kDa complex called the Atg16L complex. This complex facilitates coupling or lipidation of LC3 to phosphatidylethanolamine (PE) and this ubiquitin-like conjugation system is a widely used marker for autophagy. However, the ATG 16L complex along with other ATGs like ATG 18 and ATG 21 prevent the premature cleavage of ATG8-PE by the cysteine protease, Atg4 until the autophagosome is deemed complete.

Specifications

Antigen Atg16L1
Applications Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 0.2 mg/ml
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene ATG16L1
Gene Accession No. Q676U5
Gene Alias Autophagy-related protein 16-1, APG16-like 1, APG 16-L1, ATG16L1; APG16L. Human APG 16L isoform 2, mouse/rat APG 16 L alpha, (rat) APG16L beta isoform
Gene Symbols ATG16L1
Host Species Rabbit
Immunogen Between 50 and 100
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55054
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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