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Invitrogen™ ATG2B Polyclonal Antibody
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Catalog No. PIPA551576
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100 μL
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PIPA551576 100 μL
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Catalog No. PIPA551576 Supplier Invitrogen™ Supplier No. PA551576
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: CSKEMPRKAH SNMLTVKALH VCPESGRSPQ ECCLRVSLMP LRLNIDQDAL FFLKDFFTSL SAEVELQMTP DPEVKKSPGA DVTCSLPRHL STSKEPNLVI SFSGPKQPSQ NDSANSVEVV NGMEEKNFSA EEASFRDQPV Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 86%.

Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. Another member of the autophagy family of proteins is ATG2B, one of two homologs of ATG2 that is essential for autophagosome formation and important for regulation of size and distribution of lipid droplets. Relatively high rates of ATG2B mutations were observed in gastric and colorectal carcinomas, suggesting that deregulating the autophagy process may contribute to cancer development.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ATG2B
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene ATG2B
Gene Accession No. Q96BY7
Gene Alias 2410024A21Rik; AI047755; AI503411; ATG2 autophagy related 2 homolog B; Atg2b; autophagy related 2B; autophagy-related protein 2 homolog B; AW558123; C030004M05Rik; C14orf103; C630028L02Rik; mKIAA4067; RGD1304878
Gene Symbols ATG2B
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human ATG2B. Recombinant protein control fragment (Product #RP-88911).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55102
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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