Invitrogen™ ATG2B Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA551576

Catalog No. PIPA551576

Description

Immunogen sequence: CSKEMPRKAH SNMLTVKALH VCPESGRSPQ ECCLRVSLMP LRLNIDQDAL FFLKDFFTSL SAEVELQMTP DPEVKKSPGA DVTCSLPRHL STSKEPNLVI SFSGPKQPSQ NDSANSVEVV NGMEEKNFSA EEASFRDQPV Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 86%.

Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. Another member of the autophagy family of proteins is ATG2B, one of two homologs of ATG2 that is essential for autophagosome formation and important for regulation of size and distribution of lipid droplets. Relatively high rates of ATG2B mutations were observed in gastric and colorectal carcinomas, suggesting that deregulating the autophagy process may contribute to cancer development.

Specifications

• Antigen: ATG2B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ATG2B
• Gene Alias: 2410024A21Rik; AI047755; AI503411; ATG2 autophagy related 2 homolog B; Atg2b; autophagy related 2B; autophagy-related protein 2 homolog B; AW558123; C030004M05Rik; C14orf103; C630028L02Rik; mKIAA4067; RGD1304878
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55102
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q96BY7
• Gene Symbols: ATG2B
• Immunogen: Recombinant protein corresponding to Human ATG2B. Recombinant protein control fragment (Product #RP-88911).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov